ERAP1 overexpression in HPV-induced malignancies: A possible novel immune evasion mechanism.

ABSTRACT: Immune evasion of tumors poses a major challenge for immunotherapy. For human papillomavirus (HPV)-induced malignancies, multiple immune evasion mechanisms have been described, including altered expression of antigen processing machinery (APM) components. These changes can directly influence epitope presentation and thus T-cell responses against tumor cells. To date, the APM had not been studied systematically in a large array of HPV⁺ tumor samples. Therefore in this study, systematic expression analysis of the APM was performed on the mRNA and protein level in a comprehensive collection of HPV16⁺ cell lines. Subsequently, HPV⁺ cervical tissue samples were examined by immunohistochemistry. ERAP1 (endoplasmic reticulum aminopeptidase 1) was the only APM comp

SUBMITTER: Steinbach A 

PROVIDER: S-EPMC5543819 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature