Gene expression profiling of human lymph node metastases and matched primary breast carcinomas: clinical implications.

ABSTRACT: The genetic program that drives tumor metastasis and the mode and timing of its initiation are of great practical significance to clinical management. Modern technical advances open new opportunities for gaining useful relevant information. Gene expression profiles of histologically-verified viable tissue from lymph node metastases were compared with those of matched primary breast cancers from 10 different patients, among samples from over 400 cases, using high-throughput oligonucleotide arrays comprising probes for 22,000 genes. It was observed that metastases have very similar expression signatures to their parent tumors. However, detailed computational analysis revealed that a small number of genes were consistently differentially expressed between 100% of tumors and metastases, sugges

SUBMITTER: Suzuki M 

PROVIDER: S-EPMC5543892 | biostudies-literature | 2007 Sep

REPOSITORIES: biostudies-literature