Which ante mortem clinical features predict progressive supranuclear palsy pathology?

ABSTRACT:

Background

Progressive supranuclear palsy (PSP) is a neuropathologically defined disease presenting with a broad spectrum of clinical phenotypes.

Objective

To identify clinical features and investigations that predict or exclude PSP pathology during life, aiming at an optimization of the clinical diagnostic criteria for PSP.

Methods

We performed a systematic review of the literature published since 1996 to identify clinical features and investigations that may predict or exclude PSP pathology. We then extracted standardized data from clinical charts of patients with pathologically diagnosed PSP and relevant disease controls and calculated the sensitivity, specificity, and positive predictive value of key clinical features for PSP in this cohort.

Results

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SUBMITTER: Respondek G 

PROVIDER: S-EPMC5543934 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature