Production of Pure Aqueous ¹³ C-Hyperpolarized Acetate by Heterogeneous Parahydrogen-Induced Polarization.

ABSTRACT: A supported metal catalyst was designed, characterized, and tested for aqueous phase heterogeneous hydrogenation of vinyl acetate with parahydrogen to produce ¹³ C-hyperpolarized ethyl acetate for potential biomedical applications. The Rh/TiO₂ catalyst with a metal loading of 23.2 wt % produced strongly hyperpolarized ¹³ C-enriched ethyl acetate-1-¹³ C detected at 9.4 T. An approximately 14-fold ¹³ C signal enhancement was detected using circa 50 % parahydrogen gas without taking into account relaxation losses before and after polarization transfer by magnetic field cycling from nascent parahydrogen-derived protons to ¹³ C nuclei. This first observation of ¹³ C PHIP-hyperpolarized products over a supported metal c

SUBMITTER: Kovtunov KV 

PROVIDER: S-EPMC5544125 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature