PKC-epsilon deficiency alters progenitor cell populations in favor of megakaryopoiesis.

ABSTRACT:

Background

It has long been postulated that Protein Kinase C (PKC) is an important regulator of megakaryopoiesis. Recent contributions to the literature have outlined the functions of several individual PKC isoforms with regard to megakaryocyte differentiation and platelet production. However, the exact role of PKCε remains elusive.

Objective

To delineate the role of PKCε in megakaryopoiesis.

Approach and results

We used a PKCε knockout mouse model to examine the effect of PKCε deficiency on platelet mass, megakaryocyte mass, and bone marrow progenitor cell distribution. We also investigated platelet recovery in PKCε null mice and TPO-mediated signaling in PKCε null megakaryocytes. PKCε null mice have higher platelet counts due to increased platelet production compare

SUBMITTER: Kostyak JC 

PROVIDER: S-EPMC5544228 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature