Structure of the Arabidopsis TOPLESS corepressor provides insight into the evolution of transcriptional repression.

ABSTRACT: Transcriptional repression involves a class of proteins called corepressors that link transcription factors to chromatin remodeling complexes. In plants such as Arabidopsis thaliana, the most prominent corepressor is TOPLESS (TPL), which plays a key role in hormone signaling and development. Here we present the crystallographic structure of the Arabidopsis TPL N-terminal region comprising the LisH and CTLH (C-terminal to LisH) domains and a newly identified third region, which corresponds to a CRA domain. Comparing the structure of TPL with the mammalian TBL1, which shares a similar domain structure and performs a parallel corepressor function, revealed that the plant TPLs have evolved a new tetramerization interface and unique and highly conserved surface for interaction wit

SUBMITTER: Martin-Arevalillo R 

PROVIDER: S-EPMC5544296 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature