Human serum albumin and oxidative stress in preeclamptic women and the mechanism of albumin for stress reduction.

ABSTRACT:

Aims

The present study to address one of the mechanisms in preeclampsia, examined whether levels of oxidative stress, human serum albumin, and endothelial function correlate in pregnant women and whether human serum albumin reduces levels of superoxide produced by NADPH oxidase activation in the human vascular smooth muscle cells.

Materials and methods

Pregnant women with (Preeclampsia group, n = 33) and without preeclampsia (Normal group, n = 37) were recruited to determine levels of reactive oxygen species (serum diacron-reactive oxygen metabolite [d-ROM]), and the flow-mediated dilation (FMD). Human coronary arterial smooth muscle cells or omental arteries were subjected to evaluate isometric force recordings, levels of superoxide, western immunoblotting, and immunohistoc

SUBMITTER: Kinoshita H 

PROVIDER: S-EPMC5544496 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature