Low Bone Density and Bisphosphonate Use and the Risk of Kidney Stones.

ABSTRACT:

Background and objectives

Previous studies have demonstrated lower bone density in patients with kidney stones, but no longitudinal studies have evaluated kidney stone risk in individuals with low bone density. Small studies with short follow-up reported reduced 24-hour urine calcium excretion with bisphosphonate use. We examined history of low bone density and bisphosphonate use and the risk of incident kidney stone as well as the association with 24-hour calcium excretion.

Design, setting, participants, & measurements

We conducted a prospective analysis of 96,092 women in the Nurses' Health Study II. We used Cox proportional hazards models to adjust for age, body mass index, thiazide use, fluid intake, supplemental calcium use, and dietary factors. We also conducted a cros

SUBMITTER: Prochaska M 

PROVIDER: S-EPMC5544505 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature