Prognostic importance of left ventricular mechanical dyssynchrony in heart failure with preserved ejection fraction.

ABSTRACT:

Aims

Left ventricular mechanical dyssynchrony has been described in heart failure with preserved ejection fraction (HFpEF), but its prognostic significance is not known.

Methods and results

Of 3445 patients with HFpEF enrolled in the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial, dyssynchrony analysis was performed on 424 patients (12%) by multiple speckle tracking echocardiography strain-based criteria. The primary dyssynchrony analysis was the standard deviation of the time to peak longitudinal strain (SD T2P LS). Cox proportional hazards models assessed the association of dyssynchrony with the composite outcome of cardiovascular death or heart failure hospitalization. Mean age was 70 ± 10 years, LVEF was 60 ± 8%, and Q

SUBMITTER: Biering-Sorensen T 

PROVIDER: S-EPMC5544562 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature