Ratiometric fluorescent probe with AIE property for monitoring endogenous hydrogen peroxide in macrophages and cancer cells.

ABSTRACT: Hydrogen peroxide (H₂O₂) plays a key role in the progression of human illnesses, such as autoimmune and auto-inflammatory diseases, infectious diseases, diabetes, and cancer, etc. In this work, we have discribed a novel probe, TPE-TLE, which remarkably displayed AIE property and ratiometric fluorescence emission profiles in the presence of H₂O_2. This ratiometric fluorescent probe with AIE property exhibits outstanding features such as the well-resolved emission peaks, high sensitivity, high selectivity, low cytotoxicity, and good cell-membrane permeability. These excellent attributes enable us to demonstrate the ratiometric imaging of endogenously produced H₂O₂ in macrophages and cancer cells based on the novel ratiometric p

SUBMITTER: Liu Y 

PROVIDER: S-EPMC5544719 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature