Excessive alcohol consumption induces methane production in humans and rats.

ABSTRACT: Various studies have established the possibility of non-bacterial methane (CH₄) generation in oxido-reductive stress conditions in plants and animals. Increased ethanol input is leading to oxido-reductive imbalance in eukaryotes, thus our aim was to provide evidence for the possibility of ethanol-induced methanogenesis in non-CH₄ producer humans, and to corroborate the in vivo relevance of this pathway in rodents. Healthy volunteers consumed 1.15 g/kg/day alcohol for 4 days and the amount of exhaled CH₄ was recorded by high sensitivity photoacoustic spectroscopy. Additionally, Sprague-Dawley rats were allocated into control, 1.15 g/kg/day and 2.7 g/kg/day ethanol-consuming groups to detect the whole-body CH₄ emissions and mitochondrial functions

SUBMITTER: Tuboly E 

PROVIDER: S-EPMC5544731 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature