Surface functionalisation of nanodiamonds for human neural stem cell adhesion and proliferation.

ABSTRACT: Biological systems interact with nanostructured materials on a sub-cellular level. These interactions may govern cell behaviour and the precise control of a nanomaterial's structure and surface chemistry allow for a high degree of tunability to be achieved. Cells are surrounded by an extra-cellular matrix with nano-topographical properties. Diamond based materials, and specifically nanostructured diamond has attracted much attention due to its extreme electrical and mechanical properties, chemical inertness and biocompatibility. Here the interaction of nanodiamond monolayers with human Neural Stem Cells (hNSCs) has been investigated. The effect of altering surface functionalisation of nanodiamonds on hNSC adhesion and proliferation has shown that confluent cellular attachment occurs on oxy

SUBMITTER: Taylor AC 

PROVIDER: S-EPMC5544760 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature