High b-value diffusion-weighted imaging in progressive multifocal leukoencephalopathy in HIV patients.

ABSTRACT:

Objectives

An ill-defined hyperintense edge and hypointense core on diffusion-weighted imaging (DWI) is typical of progressive multifocal leukoencephalopathy (PML). We aimed to investigate whether a b-value of 3,000 s/mm² (b3000) can improve visualisation of PML, or provide different structural information compared to 1,000 s/mm² (b1000).

Methods

We retrospectively identified HIV-positive patients with confirmed PML studied under a clinical protocol including both b1000 and b3000 DWI. The rim and core of each PML lesion and normal-appearing white matter (NAWM) were outlined on trace-weighted DWI. Signal intensities, apparent diffusion coefficient (ADC) values and volumes were measured and compared between b1000 and b3000.

Results

Nine lesions fro

SUBMITTER: Godi C 

PROVIDER: S-EPMC5544784 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature