Repeatability and response to therapy of dynamic contrast-enhanced magnetic resonance imaging biomarkers in rheumatoid arthritis in a large multicentre trial setting.

ABSTRACT:

Objectives

To determine the repeatability and response to therapy of dynamic contrast-enhanced (DCE) MRI biomarkers of synovitis in the hand and wrist of rheumatoid arthritis (RA) patients, and in particular the performance of the transfer constant K ^trans , in a multicentre trial setting.

Methods

DCE-MRI and RA MRI scoring (RAMRIS) were performed with meticulous standardisation at baseline and 6 and 24 weeks in a substudy of fostamatinib monotherapy in reducing synovitis compared with placebo or adalimumab. Analysis employed statistical shape modelling to avoid biased regions-of-interest, kinetic modelling and heuristic analyses. Repeatability was also evaluated.

Results

At early study termination, DCE-MRI data had been acquired from 58 patients in 19 imag

SUBMITTER: Waterton JC 

PROVIDER: S-EPMC5544811 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature