Proteomic analysis of sputum reveals novel biomarkers for various presentations of asthma.

ABSTRACT:

Background

It is now recognized that asthma can present in different forms. Typically, asthma present with symptoms of wheeze, breathlessness and cough. Atypical forms of asthma such as cough variant asthma (CVA) or chest tightness variant asthma (CTVA) do not wheeze. We hypothesize that these different forms of asthma may have distinctive cellular and molecular features.

Methods

30 patients with typical or classical asthma (CA), 27 patients with CVA, 30 patients with CTVA, and 30 healthy control adults were enrolled in this prospective study. We measured serum IgE, lung function, sputum eosinophils, nitric oxide in exhaled breath (FeNO). We performed proteomic analysis of induced-sputum supernatants by mass spectrometry.

Results

There were no significant differences

SUBMITTER: Cao C 

PROVIDER: S-EPMC5544989 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature