The invasome of Salmonella Dublin as revealed by whole genome sequencing.

ABSTRACT:

Background

Salmonella enterica serovar Dublin is a zoonotic infection that can be transmitted from cattle to humans through consumption of contaminated milk and milk products. Outbreaks of human infections by S. Dublin have been reported in several countries including high-income countries. A high proportion of S. Dublin cases in humans are associated with invasive disease and systemic illness. The genetic basis of virulence in S. Dublin is not well characterized.

Methods

Whole genome sequencing was applied to a set of clinical invasive and non-invasive S. Dublin isolates from different countries in order to characterize the putative genetic determinants involved in the virulence and invasiveness of S. Dublin in humans.

Results

We identified several virulence factors

SUBMITTER: Mohammed M 

PROVIDER: S-EPMC5544996 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature