The role of alternative Polyadenylation in regulation of rhythmic gene expression.

ABSTRACT:

Background

Alternative transcription is common in eukaryotic cells and plays important role in regulation of cellular processes. Alternative polyadenylation results from ambiguous PolyA signals in 3' untranslated region (UTR) of a gene. Such alternative transcripts share the same coding part, but differ by a stretch of UTR that may contain important functional sites.

Methods

The methodoogy of this study is based on mathematical modeling, analytical solution, and subsequent validation by datamining in multiple independent experimental data from previously published studies.

Results

In this study we propose a mathematical model that describes the population dynamics of alternatively polyadenylated transcripts in conjunction with rhythmic expression such as transcription

SUBMITTER: Ptitsyna N 

PROVIDER: S-EPMC5544998 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature