MiR-451 limits CD4⁺ T cell proliferative responses to infection in mice.

ABSTRACT: MicroRNAs (miRNAs) are major regulators of cell responses, particularly in stressed cell states and host immune responses. Some miRNAs have a role in pathogen defense, including regulation of immune responses to Plasmodium parasite infection. Using a nonlethal mouse model of blood stage malaria infection, we have found that miR-451^-/- mice infected with Plasmodium yoelii XNL cleared infection at a faster rate than did wild-type (WT) mice. MiR-451^-/- mice had an increased leukocyte response to infection, with the protective phenotype primarily driven by CD4⁺ T cells. WT and miR-451^-/- CD4⁺ T cells had similar activation responses, but miR-451^-/- CD4⁺ cells had significantly increased proliferation, both in vitro an

SUBMITTER: Chapman LM 

PROVIDER: S-EPMC5545071 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature