Associations of gender and a proxy of female menopausal status with histological features of drug-induced liver injury.

ABSTRACT:

Background & aim

Gender and menopause may contribute to type and severity of drug-induced liver injury (DILI) by influencing host responses to injury. The aim of this study was to assess the associations of gender and female age 50 [a proxy of menopause] with histological features of liver injury in 212 adults enrolled in the Drug-Induced Liver Injury Network (DILIN) registry.

Methods

All participants had a causality score of at least 'probable', a liver biopsy within 30 days of DILI onset, and no prior chronic liver disease. Biochemical and histological injury types were classified as hepatocellular or cholestatic/mixed injury. The cohort was divided into three gender/age categories: men (41.0%), women <50 years (27.4%) and women ≥50 years of age (31.6%). Interaction of gen

SUBMITTER: Suzuki A 

PROVIDER: S-EPMC5545077 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature