A randomized clinical trial of vitamin D₃ (cholecalciferol) in ulcerative colitis patients with hypovitaminosis D₃.

ABSTRACT:

Aim

To prospectively evaluate the effects of vitamin D₃ on disease activity and quality of life in ulcerative colitis (UC) patients with hypovitaminosis D.

Methods

The study was a prospective double-blinded, randomized trial conducted at Community Regional Medical Center, Fresno, CA from 2012-2013. Patients with UC and a serum 25(OH)D level <30 ng/ml were eligible for the study. Enrolled subjects were randomized to receive either 2,000 IU or 4,000 IU of oral vitamin D₃ daily for a total of 90 days. The Short IBD Questionnaire (SIBDQ) for quality of life, the Partial Mayo Score for UC disease activity and serum lab tests were compared between the two treatment groups. Matched pair t-tests were computed to assess differences between the vitamin D l

SUBMITTER: Mathur J 

PROVIDER: S-EPMC5545112 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature