Donepezil Does Not Enhance Perceptual Learning in Adults with Amblyopia: A Pilot Study.

ABSTRACT: Amblyopia is a developmental disorder that results in a wide range of visual deficits. One proven approach to recovering vision in adults with amblyopia is perceptual learning (PL). Recent evidence suggests that neuromodulators can enhance adult plasticity. In this pilot study, we asked whether donepezil, a cholinesterase inhibitor, enhances visual PL in adults with amblyopia. Nine adults with amblyopia were first trained on a low-contrast single-letter identification task while taking a daily dose (5 mg) of donepezil throughout training. Following 10,000 trials of training, participants showed improved contrast sensitivity for identifying single letters. However, the magnitude of improvement was no greater than, and the rate of improvement was slower than, that obtained in a previous stud

SUBMITTER: Chung STL 

PROVIDER: S-EPMC5545606 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature