Pathophysiology of major depressive disorder: mechanisms involved in etiology are not associated with clinical progression.

ABSTRACT: Meta-analyses support the involvement of different pathophysiological mechanisms (inflammation, hypothalamic-pituitary (HPA)-axis, neurotrophic growth and vitamin D) in major depressive disorder (MDD). However, it remains unknown whether dysregulations in these mechanisms are more pronounced when MDD progresses toward multiple episodes and/or chronicity. We hypothesized that four central pathophysiological mechanisms of MDD are not only involved in etiology, but also associated with clinical disease progression. Therefore, we expected to find increasingly more dysregulation across consecutive stages of MDD progression. The sample from the Netherlands Study of Depression and Anxiety (18-65 years) consisted of 230 controls and 2333 participants assigned to a clinical staging model categorizi

SUBMITTER: Verduijn J 

PROVIDER: S-EPMC5545638 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature