Brain connectivity changes occurring following cognitive behavioural therapy for psychosis predict long-term recovery.

ABSTRACT: Little is known about the psychobiological mechanisms of cognitive behavioural therapy for psychosis (CBTp) and which specific processes are key in predicting favourable long-term outcomes. Following theoretical models of psychosis, this proof-of-concept study investigated whether the long-term recovery path of CBTp completers can be predicted by the neural changes in threat-based social affective processing that occur during CBTp. We followed up 22 participants who had undergone a social affective processing task during functional magnetic resonance imaging along with self-report and clinician-administered symptom measures, before and after receiving CBTp. Monthly ratings of psychotic and affective symptoms were obtained retrospectively across 8 years since receiving CBTp, plus self-repor

SUBMITTER: Mason L 

PROVIDER: S-EPMC5545728 | biostudies-literature | 2017 Jan

REPOSITORIES: biostudies-literature