Cognitive Status, Gray Matter Atrophy, and Lower Orthostatic Blood Pressure in Older Adults.

ABSTRACT:

Background

Associations between orthostatic blood pressure and cognitive status (CS) have been described with conflicting results.

Objective

We hypothesize that long-term exposure to lower orthostatic blood pressure is related to having worse CS later in life and that atrophy of regions involved in central regulation of autonomic function mediate these associations.

Methods

Three-to-four measures of orthostatic blood pressure were obtained from 1997-2003 in a longitudinal cohort of aging, and average systolic orthostatic blood pressure response (ASOBPR) was computed as % change in systolic blood pressure from sit-to-stand measured at one minute post stand. CS was determined in 2010-2012 by clinician-adjudication (n = 240; age = 87.1±2.6; 59% women; 37% black) with a s

SUBMITTER: O'Hare C 

PROVIDER: S-EPMC5545885 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature