Early cardiac electrographic and molecular remodeling in a model of status epilepticus and acquired epilepsy.

ABSTRACT:

Objectives

A myriad of acute and chronic cardiac alterations are associated with status epilepticus (SE) including increased sympathetic tone, rhythm and ventricular repolarization disturbances. Despite these observations, the molecular processes underlying SE-associated myocardial remodeling remain to be identified. Here we determined early SE-associated myocardial electrical and molecular alterations using a model of SE and acquired epilepsy.

Methods

We performed electrocardiography (ECG) assessments in rats beginning at 2 weeks following kainate-induced SE, and calculated short-term variability (STV) of the corrected QT intervals (QTc) as a marker of ventricular stability. Using western blotting, we quantified myocardial β1-adrenergic receptors (β1-AR) and ventricular gap

SUBMITTER: Brewster AL 

PROVIDER: S-EPMC5545890 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature