A metabolomic, geographic, and seasonal analysis of the contribution of pollen-derived adenosine to allergic sensitization.

ABSTRACT:

Background

Studies on ragweed and birch pollen extracts suggested that the adenosine content is an important factor in allergic sensitization. However, exposure levels from other pollens and considerations of geographic and seasonal factors have not been evaluated.

Objective

This study compared the metabolite profile of pollen species important for allergic disease, specifically measured the adenosine content, and evaluated exposure to pollen-derived adenosine.

Methods

An NMR metabolomics approach was used to measure metabolite concentrations in twenty-six pollen extracts. Pollen count data was analyzed from five cities to model exposure.

Results

A principal component analysis of the various metabolites identified by NMR showed that pollen extracts could be dif

SUBMITTER: Mueller GA 

PROVIDER: S-EPMC5546310 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature