Exome-based genome-wide association study and risk assessment using genetic risk score to prostate cancer in the Korean population.

ABSTRACT:

Purpose

To investigate exome-wide genetic variants associated with prostate cancer (PCa) in Koreans and evaluate the discriminative ability by the genetic risk score (GRS).

Patients and methods

We prospectively recruited 1,001 PCa cases from a tertiary hospital and conducted a case-control study including 2,641 healthy men (Stage I). Participants were analyzed using HumanExome BeadChip. For the external validation, additionally enrolled 514 PCa cases and 548 controls (independent cohort) were analyzed for the identified single nucleotide polymorphisms (SNPs) of Stage I (Stage II). The GRS was calculated as a non-weighted sum of the risk allele counts and investigated for accuracy of prediction of PCa.

Results

the mean age was 66.3 years, and the median level of prosta

SUBMITTER: Oh JJ 

PROVIDER: S-EPMC5546451 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature