β-adrenergic signaling broadly contributes to LTP induction.

ABSTRACT: Long-lasting forms of long-term potentiation (LTP) represent one of the major cellular mechanisms underlying learning and memory. One of the fundamental questions in the field of LTP is why different molecules are critical for long-lasting forms of LTP induced by diverse experimental protocols. Further complexity stems from spatial aspects of signaling networks, such that some molecules function in the dendrite and some are critical in the spine. We investigated whether the diverse experimental evidence can be unified by creating a spatial, mechanistic model of multiple signaling pathways in hippocampal CA1 neurons. Our results show that the combination of activity of several key kinases can predict the occurrence of long-lasting forms of LTP for multiple experimental protocols. Specifical

SUBMITTER: Jedrzejewska-Szmek J 

PROVIDER: S-EPMC5546712 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature