Dynamics of robust pattern separability in the hippocampal dentate gyrus.

ABSTRACT: The dentate gyrus (DG) is thought to perform pattern separation on inputs received from the entorhinal cortex, such that the DG forms distinct representations of different input patterns. Neuronal responses, however, are known to be variable, and that variability has the potential to confuse the representations of different inputs, thereby hindering the pattern separation function. This variability can be especially problematic for tissues such as the DG, in which the responses can persist for tens of seconds following stimulation: the long response duration allows for variability from many different sources to accumulate. To understand how the DG can robustly encode different input patterns, we investigated a recently developed in vitro hippocampal DG preparation that generates persistent

SUBMITTER: Zylberberg J 

PROVIDER: S-EPMC5546763 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature