A novel cause of chronic viral meningoencephalitis: Cache Valley virus.

ABSTRACT:

Objective

Immunodeficient patients are particularly vulnerable to neuroinvasive infections that can be challenging to diagnose. Metagenomic next generation sequencing can identify unusual or novel microbes and is therefore well suited for investigating the etiology of chronic meningoencephalitis in immunodeficient patients.

Methods

We present the case of a 34-year-old man with X-linked agammaglobulinemia from Australia suffering from 3 years of meningoencephalitis that defied an etiologic diagnosis despite extensive conventional testing, including a brain biopsy. Metagenomic next generation sequencing of his cerebrospinal fluid and brain biopsy tissue was performed to identify a causative pathogen.

Results

Sequences aligning to multiple Cache Valley virus genes were i

SUBMITTER: Wilson MR 

PROVIDER: S-EPMC5546801 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature