Developmentally-faithful and effective human erythropoiesis in immunodeficient and Kit mutant mice.

ABSTRACT: Immunodeficient mouse models have been valuable for studies of human hematopoiesis, but high-fidelity recapitulation of erythropoiesis in most xenograft recipients remains elusive. Recently developed immunodeficient and Kit mutant mice, however, have provided a suitable background to achieve higher-level human erythropoiesis after long-term hematopoietic engraftment. While there has been some characterization of human erythropoiesis in these models, a comprehensive analysis from various human developmental stages has not yet been reported. Here, we have utilized cell surface phenotypes, morphologic analyses, and molecular studies to fully characterize human erythropoiesis from multiple developmental stages in immunodeficient and Kit mutant mouse models following long-term hematopoietic ste

SUBMITTER: Fiorini C 

PROVIDER: S-EPMC5546987 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature