A case for motor network contributions to schizophrenia symptoms: Evidence from resting-state connectivity.

ABSTRACT: Though schizophrenia (SCZ) is classically defined based on positive symptoms and the negative symptoms of the disease prove to be debilitating for many patients, motor deficits are often present as well. A growing literature highlights the importance of motor systems and networks in the disease, and it may be the case that dysfunction in motor networks relates to the pathophysiology and etiology of SCZ. To test this and build upon recent work in SCZ and in at-risk populations, we investigated cortical and cerebellar motor functional networks at rest in SCZ and controls using publically available data. We analyzed data from 82 patients and 88 controls. We found key group differences in resting-state connectivity patterns that highlight dysfunction in motor circuits and also implicate the th

SUBMITTER: Bernard JA 

PROVIDER: S-EPMC5547006 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature