Genuine antiplasticizing effect of water on a glass-former drug.

ABSTRACT: Water is the most important plasticizer of biological and organic hydrophilic materials, which generally exhibit enhanced mechanical softness and molecular mobility upon hydration. The enhancement of the molecular dynamics upon mixing with water, which in glass-forming systems implies a lower glass transition temperature (T _g ), is considered a universal result of hydration. In fact, even in the cases where hydration or humidification of an organic glass-forming sample result in stiffer mechanical properties, the molecular mobility of the sample almost always increases with increasing water content, and its T _g decreases correspondingly. Here, we present an experimental report of a genuine antiplasticizing effect of water on the molecular dynamics of a small-molecule

SUBMITTER: Ruiz GN 

PROVIDER: S-EPMC5547059 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature