Inhibition of glycogen synthase kinase-3 by BTA-EG₄ reduces tau abnormalities in an organotypic brain slice culture model of Alzheimer's disease.

ABSTRACT: Organotypic brain slice culture models provide an alternative to early stage in vivo studies as an integrated tissue system that can recapitulate key disease features, thereby providing an excellent platform for drug screening. We recently described a novel organotypic 3xTg-AD mouse brain slice culture model with key Alzheimer's disease-like changes. We now highlight the potential of this model for testing disease-modifying agents and show that results obtained following in vivo treatment are replicated in brain slice cultures from 3xTg-AD mice. Moreover, we describe novel effects of the amyloid-binding tetra (ethylene glycol) derivative of benzothiazole aniline, BTA-EG₄, on tau. BTA-EG₄ significantly reduced tau phosphorylation in the absence of any changes in the am

SUBMITTER: Croft CL 

PROVIDER: S-EPMC5547074 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature