Secretory RAB GTPase 3C modulates IL6-STAT3 pathway to promote colon cancer metastasis and is associated with poor prognosis.

ABSTRACT:

Background

RAB GTPases are important in the regulation of membrane trafficking and cell movement. Recently, exocytic RABs have received increasing attention in cancer research. However, the functional roles of exocytic RABs in colorectal carcinogenesis remain to be elucidated.

Methods

Immunohistochemistry analysis of a microarray containing 215 colorectal adenocarcinoma tissues was used to identify the association between exocytic RABs and patient prognosis. Complementary functional RAB3C overexpression and knockdown experiments were performed. The molecular mechanism of RAB3C in inducing colon cancer cell metastasis was determined.

Results

High RAB3C expression in patients was found to be significantly associated with advanced pathological stage, distant metastasis a

SUBMITTER: Chang YC 

PROVIDER: S-EPMC5547507 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature