A new method to evaluate the dose-effect relationship of a TCM formula Gegen Qinlian Decoction: "Focus" mode of integrated biomarkers.

ABSTRACT: It is difficult to accurately evaluate the efficacy of traditional Chinese medicine (TCM), which leads to the uncertainty and complexity of dose-effect analysis. In this study we established the "Focus" mode of biomarkers to characterize the dose-effect relationship of Gegen Qinlian Decoction (GQD), a TCM formula for treating type 2 diabetes mellitus (2-DM). A rat model of 2-DM was established through high fat diet feeding combined with low-dose STZ injection. Rats with 2-DM were administered high, middle or low doses (6.785, 4.071, 1.357 mg·kg^-1·d^-1, respectively) of GQD extract for 60 d. Metformin (300 mg·kg^-1·d^-1) was taken as the positive control. Blood samples were collected to assess serum biochemical indexes and metabolic profiling. After

SUBMITTER: Huang ZQ 

PROVIDER: S-EPMC5547551 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature