Maternal Preeclampsia and Odds of Childhood Cancers in Offspring: A California Statewide Case-Control Study.

ABSTRACT:

Background

Preeclampsia is a major cause of adverse effects on fetal health. We examined associations between fetal exposure to preeclampsia and subsequent odds of childhood cancers.

Methods

We obtained childhood cancer cases (n = 13 669) diagnosed at 5 years old or younger between 1988 and 2012 from the California Cancer Registry and linked them to birth certificates. Controls (n = 271 383) were randomly selected from all California births and frequency matched to cases by birth year. We obtained data regarding preeclampsia during pregnancy, labour, and delivery from the medical worksheet of the electronic birth record. We used unconditional logistic regression models with stabilised inverse probability weights to estimate the effect of preeclampsia on each subtype of child

SUBMITTER: Xu X 

PROVIDER: S-EPMC5547573 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature