Prostaglandin dehydrogenase is a target for successful induction of cervical ripening.

ABSTRACT: The cervix represents a formidable structural barrier for successful induction of labor. Approximately 10% of pregnancies undergo induction of cervical ripening and labor with prostaglandin (PG) E₂ or PGE analogs, often requiring many hours of hospitalization and monitoring. On the other hand, preterm cervical ripening in the second trimester predicts preterm birth. The regulatory mechanisms of this paradoxical function of the cervix are unknown. Here, we show that PGE₂ uses cell-specific EP2 receptor-mediated increases in Ca²⁺ to dephosphorylate and translocate histone deacetylase 4 (HDAC4) to the nucleus for repression of 15-hydroxy prostaglandin dehydrogenase (15-PGDH). The crucial role of 15-PGDH in cervical ripening was confirmed in vivo. Although PGE<

SUBMITTER: Kishore AH 

PROVIDER: S-EPMC5547630 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature