A distinct subpopulation of CD25^- T-follicular regulatory cells localizes in the germinal centers.

ABSTRACT: T-follicular helper (Tfh) cells differentiate through a multistep process, culminating in germinal center (GC) localized GC-Tfh cells that provide support to GC-B cells. T-follicular regulatory (Tfr) cells have critical roles in the control of Tfh cells and GC formation. Although Tfh-cell differentiation is inhibited by IL-2, regulatory T (Treg) cell differentiation and survival depend on it. Here, we describe a CD25^- subpopulation within both murine and human PD1⁺CXCR5⁺Foxp3⁺ Tfr cells. It is preferentially located in the GC and can be clearly differentiated from CD25⁺ non-GC-Tfr, Tfh, and effector Treg (eTreg) cells by the expression of a wide range of molecules. In comparison to CD25⁺ Tfr and eTreg cells, CD25^-

SUBMITTER: Wing JB 

PROVIDER: S-EPMC5547636 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature