Dataset Information

Global Spread of Norovirus GII.17 Kawasaki 308, 2014-2016.

ABSTRACT: Analysis of complete capsid sequences of the emerging norovirus GII.17 Kawasaki 308 from 13 countries demonstrated that they originated from a single haplotype since the initial emergence in China in late 2014. Global spread of a sublineage SL2 was identified. A new sublineage SL3 emerged in China in 2016.

SUBMITTER: Chan MCW

PROVIDER: S-EPMC5547775 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Publications

Global Spread of Norovirus GII.17 Kawasaki 308, 2014-2016.

Chan Martin C W MCW Hu Yunwen Y Chen Haili H Podkolzin Alexander T AT Zaytseva Ekaterina V EV Komano Jun J Sakon Naomi N Poovorawan Yong Y Vongpunsawad Sompong S Thanusuwannasak Thanundorn T Hewitt Joanne J Croucher Dawn D Collins Nikail N Vinjé Jan J Pang Xiaoli L XL Lee Bonita E BE de Graaf Miranda M van Beek Janko J Vennema Harry H Koopmans Marion P G MPG Niendorf Sandra S Poljsak-Prijatelj Mateja M Steyer Andrej A White Peter A PA Lun Jennifer H JH Mans Janet J Hung Tin-Nok TN Kwok Kirsty K Cheung Kelton K Lee Nelson N Chan Paul K S PKS

Emerging infectious diseases 20170801 8

Analysis of complete capsid sequences of the emerging norovirus GII.17 Kawasaki 308 from 13 countries demonstrated that they originated from a single haplotype since the initial emergence in China in late 2014. Global spread of a sublineage SL2 was identified. A new sublineage SL3 emerged in China in 2016. ...[more]

PMID: 28726618

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Project description:BackgroundNorovirus (NoV) is a leading cause of sporadic cases and outbreaks of acute gastroenteritis (AGE). Increased NoV activity was observed in Beijing, China during winter 2014-2015; therefore, we examined the epidemiological patterns and genetic characteristics of NoV in the sporadic cases and outbreaks.MethodsThe weekly number of infectious diarrhea cases reported by all hospitals in Beijing was analyzed through the China information system for disease control and prevention. Fecal specimens were collected from the outbreaks and outpatients with AGE, and GI and GII NoVs were detected using real time reverse transcription polymerase chain reaction. The partial capsid genes and RNA-dependent RNA polymerase (RdRp) genes of NoV were both amplified and sequenced, and genotyping and phylogenetic analyses were performed.ResultsBetween December 2014 and March 2015, the number of infectious diarrhea cases in Beijing (10,626 cases) increased by 35.6% over that of the previous year (7835 cases), and the detection rate of NoV (29.8%, 191/640) among outpatients with AGE was significantly higher than in the previous year (12.9%, 79/613) (χ(2) = 53.252, P < 0.001). Between November 2014 and March 2015, 35 outbreaks of AGE were reported in Beijing, and NoVs were detected in 33 outbreaks, all of which belonged to the GII genogroup. NoVs were sequenced and genotyped in 22 outbreaks, among which 20 were caused by a novel GII.17 strain. Among outpatients with AGE, this novel GII.17 strain was first detected in an outpatient in August 2014, and it replaced GII.4 Sydney_2012 as the predominant variant between December 2014 and March 2015. A phylogenetic analysis of the capsid genes and RdRp genes revealed that this novel GII.17 strain was distinct from previously identified GII variants, and it was recently designated as GII.P17_GII.17. This variant was further clustered into two sub-groups, named GII.17_2012 and GII.17_2014. During winter 2014-2015, GII.17_2014 caused the majority of AGE outbreaks in China and Japan.ConclusionsDuring winter 2014-2015, a novel NoV GII.17 variant replaced the GII.4 variant Sydney 2012 as the predominant strain in Beijing, China and caused increased NoV activity.

Dataset Information

Global Spread of Norovirus GII.17 Kawasaki 308, 2014-2016.

Publications

Global Spread of Norovirus GII.17 Kawasaki 308, 2014-2016.

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