Dataset Information

Serologic Evidence of Powassan Virus Infection in Patients with Suspected Lyme Disease¹.

ABSTRACT: Powassan virus (POWV) lineage II is an emerging tickborne flavivirus with an unknown seroprevalence in humans. In a Lyme disease-endemic area, we examined the seroreactivity to POWV in 2 patient cohorts and described the clinical features of the POWV-seroreactive patients. POWV disease might be less neuroinvasive than previously thought.

SUBMITTER: Frost HM

PROVIDER: S-EPMC5547799 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Serologic Evidence of Powassan Virus Infection in Patients with Suspected Lyme Disease<sup>1</sup>.

Frost Holly M HM Schotthoefer Anna M AM Thomm Angela M AM Dupuis Alan P AP Kehl Sue C SC Kramer Laura D LD Fritsche Thomas R TR Harrington Yvette A YA Knox Konstance K KK

Emerging infectious diseases 20170801 8

Powassan virus (POWV) lineage II is an emerging tickborne flavivirus with an unknown seroprevalence in humans. In a Lyme disease-endemic area, we examined the seroreactivity to POWV in 2 patient cohorts and described the clinical features of the POWV-seroreactive patients. POWV disease might be less neuroinvasive than previously thought. ...[more]

PMID: 28726610

Similar Datasets

Project description:Background and aimThe pandemic (H1N1) 2009 influenza (H1N1pdm09) virus has affected both human and animal populations worldwide. The transmission of the H1N1pdm09 virus from humans to animals is increasingly more evident. Captive animals, particularly zoo animals, are at risk of H1N1pdm09 virus infection through close contact with humans. Evidence of exposure to the H1N1pdm09 virus has been reported in several species of animals in captivity. However, there is limited information on the H1N1pdm09 virus infection and circulation in captive animals. To extend the body of knowledge on exposure to the H1N1pdm09 virus among captive animals in Thailand, our study investigated the presence of antibodies against the H1N1pdm09 virus in two captive animals: Camelids and Eld's deer.Materials and methodsWe investigated H1N1pdm09 virus infection among four domestic camelid species and wild Eld's deer that were kept in different zoos in Thailand. In total, 72 archival serum samples from camelid species and Eld's deer collected between 2013 and 2014 in seven provinces in Thailand were analyzed for influenza antibodies using hemagglutination inhibition (HI), microneutralization, and western blotting (WB) assays.ResultsThe presence of antibodies against the H1N1pdm09 virus was detected in 2.4% (1/42) of dromedary camel serum samples and 15.4% (2/13) of Eld's deer serum samples. No antibodies were detected in the rest of the serum samples derived from other investigated camelids, including Bactrian camels (0/3), alpacas (0/5), and llamas (0/9). The three positive serum samples showed HI antibody titers of 80, whereas the neutralization titers were in the range of 320-640. Antibodies specific to HA and NP proteins in the H1N1pdm09 virus were detected in positive camel serum samples using WB. Conversely, the presence of the specific antibodies in the positive Eld's deer serum samples could not be determined using WB due to the lack of commercially labeled secondary antibodies.ConclusionThe present study provided evidence of H1N1pdm09 virus infection in the captive dromedary camel and Eld's deer in Thailand. Our findings highlight the need for continuous surveillance for influenza A virus in the population of dromedary camels and Eld's deer. The susceptible animal populations in close contact with humans should be closely monitored. Further study is warranted to determine whether Eld's deer are indeed a competent reservoir for human influenza virus.

Dataset Information

Serologic Evidence of Powassan Virus Infection in Patients with Suspected Lyme Disease¹.

Publications

Serologic Evidence of Powassan Virus Infection in Patients with Suspected Lyme Disease<sup>1</sup>.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Serologic Evidence of Powassan Virus Infection in Patients with Suspected Lyme Disease1.

Publications

Serologic Evidence of Powassan Virus Infection in Patients with Suspected Lyme Disease<sup>1</sup>.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Serologic Evidence of Powassan Virus Infection in Patients with Suspected Lyme Disease¹.