Differences in Survival With Surgery and Postoperative Radiotherapy Compared With Definitive Chemoradiotherapy for Oral Cavity Cancer: A National Cancer Database Analysis.

ABSTRACT:

Importance

Because locally advanced oral cavity squamous cell carcinoma (OCSCC) is often treated with surgery followed by postoperative radiotherapy (S+PORT), the effectiveness of organ preservation with concurrent chemoradiotherapy (CRT) remains unclear.

Objective

To compare the differences in survival between patients with locally advanced OCSCC treated with S+PORT or CRT.

Design, setting, and participants

Using the National Cancer Database, this study compared 6900 patients with stage III to IVA OCSCC treated with S+PORT and CRT from 2004 through 2012 at academic and community-based cancer clinics. Comparisons were made using Kaplan-Meier methods and Cox proportional hazards regression models using the entire cohort and a propensity score-matched cohort of 2286 pat

SUBMITTER: Spiotto MT 

PROVIDER: S-EPMC5547927 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature