Variant SNPs at the microRNA complementary site in the B7‑H1 3'‑untranslated region increase the risk of non‑small cell lung cancer.

ABSTRACT: Single nucleotide polymorphisms (SNPs) in microRNA‑binding sites located in the 3'‑untranslated region (UTR) of target genes can have an effect on the interaction of microRNA‑mediated regulation, which results in changes in the expression levels of target genes ultimately associated with cancer risk and patient prognosis. However, the role of SNPs at the 3'‑UTR of B7‑H1 in the susceptibility of non‑small cell lung cancer (NSCLC) remains to be fully elucidated. In the present study, SNPs with a minor allele frequency >10%, which were located at the microRNA complementary site in the PD‑L1 3'‑UTR, were selected via bioinformatic prediction using Ensembl and miRanda 2010. A total of three SNPs were selected, s2297136, rs4143815 and rs4742098, in the 3'‑UTR of B7‑H1. The rs2297136 and rs474209

SUBMITTER: Du W 

PROVIDER: S-EPMC5547930 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature