Exploration of the sequential gene changes in epithelial ovarian cancer induced by carboplatin via microarray analysis.

ABSTRACT: The purpose of the current study was to explore the carboplatin‑induced sequential changes in gene expression and screen out key genes, which were associated with effects of carboplatin on epithelial ovarian cancer (EOC). The microarray dataset GSE13525 was downloaded from the Gene Expression Omnibus database, including 6 EOC cell samples separately treated with carboplatin at 24, 30 and 36 h (case group), and 6 samples treated with phosphate‑buffered saline at the same time points (control group). A total of 3 sets of differentially expressed genes (DEGs) were respectively identified in case samples at 24, 30 and 36 h compared with the control group via the Limma package, and separately recorded as DEG‑24, DEG‑30 and DEG‑36. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (

SUBMITTER: Wei S 

PROVIDER: S-EPMC5547949 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature