Completion Dissection or Observation for Sentinel-Node Metastasis in Melanoma.

ABSTRACT:

Background

Sentinel-lymph-node biopsy is associated with increased melanoma-specific survival (i.e., survival until death from melanoma) among patients with node-positive intermediate-thickness melanomas (1.2 to 3.5 mm). The value of completion lymph-node dissection for patients with sentinel-node metastases is not clear.

Methods

In an international trial, we randomly assigned patients with sentinel-node metastases detected by means of standard pathological assessment or a multimarker molecular assay to immediate completion lymph-node dissection (dissection group) or nodal observation with ultrasonography (observation group). The primary end point was melanoma-specific survival. Secondary end points included disease-free survival and the cumulative rate of nonsentinel-node m

SUBMITTER: Faries MB 

PROVIDER: S-EPMC5548388 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature