Functional neural changes following behavioral therapies and disulfiram for cocaine dependence.

ABSTRACT: A growing literature exists on neural correlates of treatment outcome. However, different types-or components of-treatment have distinct theorized mechanisms of action. And it is not yet known how changes in neural activity across treatment relate to engagement in different treatment components. Participants with cocaine use disorders in a randomized clinical trial received cognitive-behavioral therapy (CBT) plus, in a 2 × 2 design, contingency management (CM) or no CM, and disulfiram or placebo. Participants performed a functional MRI Stroop task, a measure of cognitive control, at the beginning of and after the 12-week treatment. Analyses assessed changes in Stroop-related neural activity within the sample overall and assessed how changes in Stroop-related activity correlated with measur

SUBMITTER: DeVito EE 

PROVIDER: S-EPMC5548432 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature