Separating blood and water: Perfusion and free water elimination from diffusion MRI in the human brain.

ABSTRACT: The assessment of the free water fraction in the brain provides important information about extracellular processes such as atrophy and neuroinflammation in various clinical conditions as well as in normal development and aging. Free water estimates from diffusion MRI are assumed to account for freely diffusing water molecules in the extracellular space, but may be biased by other pools of molecules in rapid random motion, such as the intravoxel incoherent motion (IVIM) of blood, where water molecules perfuse in the randomly oriented capillary network. The goal of this work was to separate the signal contribution of the perfusing blood from that of free-water and of other brain diffusivities. The influence of the vascular compartment on the estimation of the free water fraction and other d

SUBMITTER: Rydhog AS 

PROVIDER: S-EPMC5548601 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature