Study Design Rigor in Animal-Experimental Research Published in Anesthesia Journals.

ABSTRACT:

Background

Lack of reproducibility of preclinical studies has been identified as an impediment for translation of basic mechanistic research into effective clinical therapies. Indeed, the National Institutes of Health has revised its grant application process to require more rigorous study design, including sample size calculations, blinding procedures, and randomization steps. We hypothesized that the reporting of such metrics of study design rigor has increased over time for animal-experimental research published in anesthesia journals.

Methods

PubMed was searched for animal-experimental studies published in 2005, 2010, and 2015 in primarily English-language anesthesia journals. A total of 1466 publications were graded on the performance of sample size estimation, randomiz

SUBMITTER: Hoerauf JM 

PROVIDER: S-EPMC5548642 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature