Anti-colon cancer effect of caffeic acid p-nitro-phenethyl ester in vitro and in vivo and detection of its metabolites.

ABSTRACT: Caffeic acid phenethyl ester (CAPE), extracted from propolis, was proven to inhibit colon cancer. Caffeic acid p-nitro-phenethyl ester (CAPE-pNO₂), a derivative of CAPE, was determined to be an anti-platelet agent and a protector of myocardial ischaemia with more potent effects. In the present study, CAPE-pNO₂ showed stronger cytotoxic activity than CAPE. We revealed interactions between CAPE-pNO₂ and experimental cells. CAPE-pNO₂ induced apoptosis in HT-29 cells by up-regulating P53, cleaved-caspase-3, Bax, P38 and CytoC; CAPE-pNO₂ also up-regulated P21^Cip1 and P27^Kip1 and down-regulated CDK2 and c-Myc to promote cell cycle arrest in G0/G1. In xenograft studies, CAPE-pNO₂ remarkably suppressed tumour g

SUBMITTER: Tang H 

PROVIDER: S-EPMC5548715 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature