Three TF Co-expression Modules Regulate Pressure-Overload Cardiac Hypertrophy in Male Mice.

ABSTRACT: Pathological cardiac hypertrophy, a dynamic remodeling process, is a major risk factor for heart failure. Although a number of key regulators and related genes have been identified, how the transcription factors (TFs) dynamically regulate the associated genes and control the morphological and electrophysiological changes during the hypertrophic process are still largely unknown. In this study, we obtained the time-course transcriptomes at five time points in four weeks from male murine hearts subjected to transverse aorta banding surgery. From a series of computational analyses, we identified three major co-expression modules of TF genes that may regulate the gene expression changes during the development of cardiac hypertrophy in mice. After pressure overload, the TF genes in Module 1 wer

SUBMITTER: Chang YM 

PROVIDER: S-EPMC5548763 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature